A consensus in aerospace industry is that for Integrated Vehicle Health Management (IVHM) technology to fully achieve its promise there is a need in establishing open architectures and standards. An open architecture would facilitate interaction of aircraft primes, subsystem OEMs, aircraft operators, government regulators, and research community in development and integration of IVHM systems from best available components. To answer this need, the IVHM Project in the NASA Aviation Safety Program is working on establishing an architectural framework for IVHM interoperability. This paper describes a NASA-led effort in IVHM architecture. The interoperability framework includes standardization of operations, functions, protocols, and information management models. NASA IVHM Project sponsors many new technology developments and expects that establishing the architectural framework would facilitate the technology transition to industry.